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Asthma

- episodic, reversible bronchospasm
resulting from an exaggerated bronchoconstrictor response to various stimuli
- clinically
manifested by episodic dyspnea, cough, wheezing1)1). soft whistling sound during expiration

Types of Asthma
Precipitating Factors
Mechanism or
Immunologic Reaction
Extrinsic

Atopic (allergic)
specific antigens
Type I (IgE) immune
reaction
Occupational
Chemical challenge
Type I hypersensitivity
immune reactions
Allergic broncho-
pulmonary aspergillosis
Antigen(spores)
Type I and Type III
hypersensitivity immune
reactions
Intrinsic

Nonreaginic
respiratory tract
infection
Unknown:
hyperreactive airways
Pharmacologic
(e.g. aspirin-sensitive)
Aspirin
Decreased prostaglandins,
increased leukotrienes

1. Extrinsic asthma
a. Atopic (allergic)
: most common type of asthma
b. Occupational
c. Allergic bronchopulmonary aspergillosis
....

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